SNAC in Oral Semaglutide Tied to Gut Bacteria Disruption

A 2026 rat study suggests that SNAC, the absorption enhancer used in oral semaglutide (Rybelsus), may alter gut microbiota and increase inflammatory markers. While intriguing, the findings are preliminary and based on animal data. Experts say the benefits of semaglutide remain well established, and human studies are needed.